AN DIEGO, January 20, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with low-dose cytarabine for the treatment of acute myeloid leukemia (AML) in older patients. In addition to a global phase 2/3 study in malignant plural mesothelioma featuring ADI‑PEG 20 in combination with pemetrexed and cisplatin, Polaris Group is currently conducting multiple phase 1 clinical trials, including ADI‑PEG 20 in combination with pemetrexed and cisplatin in non-small cell lung carcinoma, glioblastoma, and uveal melanoma, in combination with gemcitabine and paclitaxel in pancreatic cancer and in combination with FOLFOX in hepatocellular carcinoma, gastric cancer, and colorectal cancer.
“We hope that the addition of ADI‑PEG 20, which has a different mechanism of action than cytarabine, will result in both safety and added efficacy”, said John Bomalaski, M.D., Executive Vice President, Medical Affairs at Polaris Pharmaceuticals, Inc.
About ADI‑PEG 20
ADI‑PEG 20 is a biologic being developed by Polaris Group to treat cancers carrying a major metabolic defect that renders them unable to internally synthesize arginine. Because arginine is essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI‑PEG 20 is designed to deplete the external supply of arginine, causing arginine-dependent cancer cells to die while leaving the patient’s normal cells unharmed. Multiple cancers have been reported to have a high degree of arginine-dependency and can potentially be treated with ADI‑PEG 20.
About Polaris Group
Polaris Group specializes in the research and development of protein drugs to treat cancer and other debilitating diseases. In addition to the ADI‑PEG 20 program, Polaris Group is developing other biotherapeutic agents including a small molecule drug program that utilizes a rational structure-based approach to design novel compounds that inhibit the biological function of cancer-related protein targets.