SAN DIEGO, January 10, 2018 – Polaris Group announced today that the combination of its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) with the standard first-line chemotherapy cisplatin + pemetrexed doublet (PemCis) has shown promising clinical activity in an ongoing phase 1 study cohort of non-squamous non-small cell lung carcinoma (NSCLC) patients…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Polarispharmahttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngPolarispharma2018-01-10 00:00:582018-05-08 09:47:50Polaris Group’s ADI‑PEG 20 Shows Promising Clinical Activity in NSCLC When Combined with Standard First Line Chemotherapy Regimen
SAN DIEGO, September 12, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) demonstrated a good safety profile and an efficacy signal as monotherapy in a phase 2 trial in relapsed/refractory or poor-risk acute myeloid leukemia (AML) patients, as reported in the journal Scientific…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-09-12 14:03:002018-01-17 15:18:47Polaris Announces Results of a Phase 2 Trial of ADI‑PEG 20 in Relapsed/Refractory or Poor-risk Acute Myeloid Leukemia
SAN DIEGO, August 2, 2017 – Polaris Group announced today that the first patient has been dosed in its randomized, placebo-controlled, double blind phase 2/3 trial (ATOMIC-meso) in malignant pleural mesothelioma (MPM) patients. Patients will be randomized to receive ADI‑PEG 20 (pegylated arginine deiminase) or placebo in combination with pemetrexed…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-08-02 10:30:002018-01-17 15:16:49Polaris Group Announces Treatment of First Patient in Phase 2/3 Study of ADI‑PEG 20 Plus Cisplatin and Pemetrexed in Malignant Pleural Mesothelioma
SAN DIEGO, July 14, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with pembrolizumab for the treatment of advanced solid tumors. In addition to a global phase 2/3 trial in malignant plural mesothelioma featuring ADI‑PEG…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-07-14 15:05:412018-01-17 15:17:40Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI‑PEG 20 Plus Pembrolizumab in Advanced Solid Tumors
SAN DIEGO, June 5, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) in combination with pemetrexed and cisplatin (ADIPemCis) is active in argininosuccinate synthetase (ASS1) deficient malignant pleural mesothelioma (MPM), including non-epithelioid MPM, which carries an unfavorable prognosis and historically responds poorly to…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-06-05 15:07:422018-01-17 15:18:10Polaris Lead Therapeutic ADI‑PEG 20 in Combination with First Line Chemotherapy Is Active in Argininosuccinate Synthetase Deficient Mesothelioma
SAN DIEGO, April 20, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) in combination with pemetrexed and cisplatin (ADIPemCis) demonstrated a good safety profile and a strong efficacy signal in argininosuccinate synthetase (ASS1) deficient malignant pleural mesothelioma (MPM) and non-small cell lung carcinoma…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-04-20 15:21:072018-01-17 15:21:22Polaris Provides Early Evidence of Response to Arginine Depletion by ADI‑PEG 20 in Argininosuccinate Synthetase Deficient Thoracic Tumors
SAN DIEGO, January 20, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with low-dose cytarabine for the treatment of acute myeloid leukemia (AML) in older patients. In addition to a global phase 2/3 study in…
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2017-01-20 15:23:492018-01-17 15:25:06Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI‑PEG 20 Plus Cytarabine in Older Patients with Acute Myeloid Leukemia
SAN DIEGO, January 19, 2017 – Polaris Group announced today results from an ongoing phase 1b study conducted at Memorial Sloan Kettering Cancer Center that tests combining ADI‑PEG 20 with folinic acid (leucovorin), fluorouracil and oxaliplatin (FOLFOX) in patients with advanced hepatocellular carcinoma (HCC) and other gastrointestinal malignancies. The results will be presented at the 2017 Gastrointestinal Cancers Symposium in San Francisco.
SAN DIEGO, Nov. 8, 2016 /PRNewswire/ — Polaris Group announced today that ADI‑PEG 20, arginine deiminase formulated with polyethylene glycol, can selectively enhance the effect of radiation in argininosuccinate synthetase (ASS1) deficient pancreatic tumors according to results presented by researchers from MD Anderson Cancer Center at the annual meeting of the American Society for Radiation Oncology (ASTRO).
http://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.png00Emmyhttp://polarispharma.com/wp-content/uploads/Polaris_Logo_FullColor_Old-350x96-350x96.pngEmmy2016-11-08 09:12:042018-02-19 09:15:21ADI‑PEG 20 Radio-sensitizes Pancreatic Cancer Cells by Amplifying Early Endoplasmic Reticulum Stress
SAN DIEGO, Oct. 24, 2016 /PRNewswire/ — Polaris Group announced today that ADI‑PEG 20, arginine deiminase formulated with polyethylene glycol, can boost anti-tumor immune surveillance according to research presented by Polaris at the 2016 American Association for Cancer Research Tumor Immunology and Immunotherapy conference in Boston.
Polaris Group’s ADI‑PEG 20 Shows Promising Clinical Activity in NSCLC When Combined with Standard First Line Chemotherapy Regimen
NewsSAN DIEGO, January 10, 2018 – Polaris Group announced today that the combination of its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) with the standard first-line chemotherapy cisplatin + pemetrexed doublet (PemCis) has shown promising clinical activity in an ongoing phase 1 study cohort of non-squamous non-small cell lung carcinoma (NSCLC) patients…
Polaris Announces Results of a Phase 2 Trial of ADI‑PEG 20 in Relapsed/Refractory or Poor-risk Acute Myeloid Leukemia
NewsSAN DIEGO, September 12, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) demonstrated a good safety profile and an efficacy signal as monotherapy in a phase 2 trial in relapsed/refractory or poor-risk acute myeloid leukemia (AML) patients, as reported in the journal Scientific…
Polaris Group Announces Treatment of First Patient in Phase 2/3 Study of ADI‑PEG 20 Plus Cisplatin and Pemetrexed in Malignant Pleural Mesothelioma
NewsSAN DIEGO, August 2, 2017 – Polaris Group announced today that the first patient has been dosed in its randomized, placebo-controlled, double blind phase 2/3 trial (ATOMIC-meso) in malignant pleural mesothelioma (MPM) patients. Patients will be randomized to receive ADI‑PEG 20 (pegylated arginine deiminase) or placebo in combination with pemetrexed…
Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI‑PEG 20 Plus Pembrolizumab in Advanced Solid Tumors
NewsSAN DIEGO, July 14, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with pembrolizumab for the treatment of advanced solid tumors. In addition to a global phase 2/3 trial in malignant plural mesothelioma featuring ADI‑PEG…
Polaris Lead Therapeutic ADI‑PEG 20 in Combination with First Line Chemotherapy Is Active in Argininosuccinate Synthetase Deficient Mesothelioma
NewsSAN DIEGO, June 5, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) in combination with pemetrexed and cisplatin (ADIPemCis) is active in argininosuccinate synthetase (ASS1) deficient malignant pleural mesothelioma (MPM), including non-epithelioid MPM, which carries an unfavorable prognosis and historically responds poorly to…
Polaris Provides Early Evidence of Response to Arginine Depletion by ADI‑PEG 20 in Argininosuccinate Synthetase Deficient Thoracic Tumors
NewsSAN DIEGO, April 20, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) in combination with pemetrexed and cisplatin (ADIPemCis) demonstrated a good safety profile and a strong efficacy signal in argininosuccinate synthetase (ASS1) deficient malignant pleural mesothelioma (MPM) and non-small cell lung carcinoma…
Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI‑PEG 20 Plus Cytarabine in Older Patients with Acute Myeloid Leukemia
NewsSAN DIEGO, January 20, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with low-dose cytarabine for the treatment of acute myeloid leukemia (AML) in older patients. In addition to a global phase 2/3 study in…
ADI‑PEG 20 plus FOLFOX Shows Robust Anti-tumor Activity in Advanced Hepatocellular Carcinoma
NewsSAN DIEGO, January 19, 2017 – Polaris Group announced today results from an ongoing phase 1b study conducted at Memorial Sloan Kettering Cancer Center that tests combining ADI‑PEG 20 with folinic acid (leucovorin), fluorouracil and oxaliplatin (FOLFOX) in patients with advanced hepatocellular carcinoma (HCC) and other gastrointestinal malignancies. The results will be presented at the 2017 Gastrointestinal Cancers Symposium in San Francisco.
ADI‑PEG 20 Radio-sensitizes Pancreatic Cancer Cells by Amplifying Early Endoplasmic Reticulum Stress
NewsSAN DIEGO, Nov. 8, 2016 /PRNewswire/ — Polaris Group announced today that ADI‑PEG 20, arginine deiminase formulated with polyethylene glycol, can selectively enhance the effect of radiation in argininosuccinate synthetase (ASS1) deficient pancreatic tumors according to results presented by researchers from MD Anderson Cancer Center at the annual meeting of the American Society for Radiation Oncology (ASTRO).
ADI‑PEG 20 Can Boost Anti-Tumor Immune Surveillance
NewsSAN DIEGO, Oct. 24, 2016 /PRNewswire/ — Polaris Group announced today that ADI‑PEG 20, arginine deiminase formulated with polyethylene glycol, can boost anti-tumor immune surveillance according to research presented by Polaris at the 2016 American Association for Cancer Research Tumor Immunology and Immunotherapy conference in Boston.