Polaris Group Announces Results of a Phase 1 Clinical Study with its Lead Therapeutic Candidate ADI‑PEG 20 in Metastatic Uveal Melanomas

SAN DIEGO, June 05, 2018 – Polaris Group, a biopharmaceutical company focused on developing novel drugs for cancer, announced results from a phase 1 clinical study that features Polaris lead therapeutic candidate ADI-PEG 20 in combination with pemetrexed and cisplatin (ADIPEMCIS) in first-line treatment for argininosuccinate synthetase (ASS1) deficient metastatic uveal melanomas…

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Polaris Group Announces Results of a Phase 1 Clinical Study with its Lead Therapeutic Candidate ADI-PEG 20 in Combination with Pembrolizumab for Advanced Solid Tumors

SAN DIEGO, June 04 2018 – At the American Society Clinical Oncology’s 2018 annual meeting, scientists from National Institute of Cancer Research Taiwan reported results from a phase 1 clinical study, showing that Polaris lead therapeutic candidate ADI-PEG 20 in combination with pembrolizumab has activity for advanced solid tumors…

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Polaris Group Presents Results for Phase 1 Clinical Study with its Lead Therapeutic Candidate ADI‑PEG 20 Plus FOLFOX in Hepatocellular Carcinoma

SAN DIEG0, June 03 2018 – Polaris Group announced results from a phase 1 clinical study, showing that Polaris lead therapeutic candidate ADI-PEG 20 in combination with FOLFOX demonstrated promising efficacy for heavily pre-treated hepatocellular carcinoma (HCC) patients…

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Polaris Group Announces Treatment of First Patient in a Phase 2 Study of ADI‑PEG 20 Plus Gemcitabine and Docetaxel for Soft Tissue Sarcoma

SAN DIEGO, May 31, 2018 – Polaris Group announced today that the first patient has been dosed in a phase 2 trial of ADI‑PEG 20 in combination with gemcitabine and docetaxel for the treatment of soft tissue sarcoma, sponsored by Washington University…

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Polaris Signs Collaboration Agreement with MD Anderson Cancer Center to Join its Immunotherapy Platform for Clinical Trials and Preclinical Research

SAN DIEGO, May 10, 2018 – Polaris Group announced that it has signed a multiyear strategic Collaboration Agreement with MD Anderson Cancer Center to utilize its Immunotherapy Platform, led by world-renowned immunotherapy pioneer Dr. James Allison, Dr. Padmanee Sharma, and Dr. Patrick Hwu, to design clinical studies and monitor biomarkers in immune functions associated with the therapies…

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ADI‑PEG 20 and PD-1/PD-L1 Blockade Lead to Strong Anti-tumor Activity in ASS1- and PD-L1-negative Fibrosarcoma Murine Model

SAN DIEGO, March 26, 2018 – Polaris Group announced today that its lead product ADI‑PEG 20 modulates PD-L1 expression via stimulating the release of IFN-a and -b in several tumor cell lines and the combination of ADI‑PEG 20 and PD-1/PD-L1 blockade abrogated tumorigenesis in a murine model according to research presented by a group from Barts Cancer Institute, London …

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Polaris Group’s ADI‑PEG 20 Shows Promising Clinical Activity in NSCLC When Combined with Standard First Line Chemotherapy Regimen

SAN DIEGO, January 10, 2018 – Polaris Group announced today that the combination of its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) with the standard first-line chemotherapy cisplatin + pemetrexed doublet (PemCis) has shown promising clinical activity in an ongoing phase 1 study cohort of non-squamous non-small cell lung carcinoma (NSCLC) patients…

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Polaris Announces Results of a Phase 2 Trial of ADI‑PEG 20 in Relapsed/Refractory or Poor-risk Acute Myeloid Leukemia

SAN DIEGO, September 12, 2017 – Polaris Group announced today that its lead therapeutic ADI‑PEG 20 (pegylated arginine deiminase) demonstrated a good safety profile and an efficacy signal as monotherapy in a phase 2 trial in relapsed/refractory or poor-risk acute myeloid leukemia (AML) patients, as reported in the journal Scientific…

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Polaris Group Announces Treatment of First Patient in Phase 2/3 Study of ADI‑PEG 20 Plus Cisplatin and Pemetrexed in Malignant Pleural Mesothelioma

SAN DIEGO, August 2, 2017 – Polaris Group announced today that the first patient has been dosed in its randomized, placebo-controlled, double blind phase 2/3 trial (ATOMIC-meso) in malignant pleural mesothelioma (MPM) patients. Patients will be randomized to receive ADI‑PEG 20 (pegylated arginine deiminase) or placebo in combination with pemetrexed…

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Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI‑PEG 20 Plus Pembrolizumab in Advanced Solid Tumors

SAN DIEGO, July 14, 2017 – Polaris Group announced today that the first patient has been dosed in its phase 1 trial of ADI‑PEG 20 in combination with pembrolizumab for the treatment of advanced solid tumors. In addition to a global phase 2/3 trial in malignant plural mesothelioma featuring ADI‑PEG…

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